Phenotypes for Prickle3 MGI:6514802 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Prickle3^em1Mxg/Y
Genetic Background	C57BL/6JSlacc-Prickle3^em1Mxg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle3^em1Mxg mutation (0 available); any Prickle3 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina blood vessel morphology ( J:300151 )

• tortuous and dilated with more branches in vessels

increased retina vascular tortuosity ( J:300151 )

retina ganglion cell degeneration ( J:300151 )

abnormal cone electrophysiology ( J:300151 )

• reduced b-wave

abnormal rod electrophysiology ( J:300151 )

• reduced b-wave

nervous system

abnormal retina ganglion cell dendrite morphology ( J:300151 )

retina ganglion cell degeneration ( J:300151 )

cardiovascular system

abnormal retina blood vessel morphology ( J:300151 )

• tortuous and dilated with more branches in vessels

increased retina vascular tortuosity ( J:300151 )

cellular

abnormal mitochondrial morphology ( J:300151 )

• with vacuolated, fragmented mitochondria and the loss of cristae in the retina

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Leber plus disease		DOID:0111754		J:300151

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23