Phenotypes Associated with This Genotype

Genotype
MGI:6511251

• Allelic Composition: Cmtm6^{tm1c(EUCOMM)Wtsi}/Cmtm6^{tm1c(EUCOMM)Wtsi}; Tg(Dhh-cre)1Mejr/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:296495 )

N • normal internode length and nodal and paranodal dimensions

N • normal neurofilament density and phosphorylation

abnormal axon morphology ( J:296495 )

• increased diameter of phrenic and ventral tail nerve axons

• increased diameter of non-myelinated sciatic nerve axons in Remak bundles at ages P9 and 2 months

• normal myelin sheath thickness to axon diameter ratio for phrenic and ventral tail nerve axons

• normal number of axons per Remak bundle, with no axon diameters larger than 1 micrometer

• normal frequency of developmentally sorted promyelinated axons

abnormal action potential ( J:296495 )

• increased sensory nerve action potential (SNAP)

increased nerve conduction velocity ( J:296495 )

• increased sensory nerve conduction velocity (SNCV)

behavior/neurological

abnormal gait ( J:296495 )

• increased slipping when walking over a regular grid

decreased thermal nociceptive threshold ( J:296495 )

• accelerated reaction in hot plate test

respiratory system

abnormal pulmonary respiratory rate ( J:296495 )

• absence of spontaneous apnea