Phenotypes Associated with This Genotype

Genotype
MGI:6510851

• Allelic Composition: Rasa3^tm1a(KOMP)J/Rasa3^tm1a(KOMP)J; Tg(CMV-cre)1Cgn/?
• Genetic Background: (C57BL/6N-Rasa3^tm1a(KOMP)J/J x B6.C-Tg(CMV-cre)1Cgn/J)F2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hemorrhage ( J:301035 )

• severe hemorrhage found in E12.5-E13.5 homozygotes

liver/biliary system

pale liver ( J:301035 )

• small, pale fetal liver at E12.5-E13.5

integument

pallor ( J:301035 )

mortality/aging

embryonic lethality, complete penetrance ( J:301035 )

• intercrosses of heterozygotes in the presence of a cre deleter yield no homozygous null animals at birth, showing the homozygous lethality and phenotypes of the null allele