Phenotypes Associated with This Genotype

Genotype
MGI:6510020

• Allelic Composition: Spata19^tm1Lij/Spata19^tm1Lij; Tg(Stra8-icre)1Reb/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm flagellum morphology ( J:301706 )

♂ • all sperm show tail defects

abnormal sperm mitochondrial sheath morphology ( J:301706 )

♂ • severe defects in the sheaths in the midpiece

abnormal sperm mitochondrial morphology ( J:301706 )

♂ • mitochondria are variable in size and have an irregular appearance

decreased sperm progressive motility ( J:301706 )

♂ • severely reduced

male infertility ( J:301706 )

♂ • males are infertile despite displaying normal mating behavior

♂ • male infertility can be bypassed using intracytoplasmic sperm injection

cellular

abnormal sperm flagellum morphology ( J:301706 )

♂ • all sperm show tail defects

abnormal sperm mitochondrial sheath morphology ( J:301706 )

♂ • severe defects in the sheaths in the midpiece

abnormal sperm mitochondrial morphology ( J:301706 )

♂ • mitochondria are variable in size and have an irregular appearance

decreased sperm progressive motility ( J:301706 )

♂ • severely reduced

abnormal respiratory electron transport chain ( J:301706 )

♂ • significant decrease in the relative activities of the mitochondrial respiratory chain complex IV and lower ATP levels in sperm samples