Phenotypes for Pcdhg Tg(Pax6-cre,GFP)2Pgr MGI:6509336 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pcdhg^em5Rwb/Pcdhg^tm2Xzw Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhg^em5Rwb mutation (0 available); any Pcdhg mutation (13 available)
Pcdhg^tm2Xzw mutation (1 available); any Pcdhg mutation (13 available)
Tg(Pax6-cre,GFP)2Pgr mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

decreased amacrine cell number ( J:285314 )

decreased retina ganglion cell number ( J:285314 )

thin retina inner nuclear layer ( J:285314 )

thin retina inner plexiform layer ( J:285314 )

decreased total retina thickness ( J:285314 )

• At 14 days of age the inner retina is thinner than normal in both cellular and synaptic layers, but neurite stratification is not disorganized

nervous system

decreased amacrine cell number ( J:285314 )

decreased retina ganglion cell number ( J:285314 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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