Phenotypes Associated with This Genotype

Genotype
MGI:6509149

• Allelic Composition: Nlrc4^em2Vnce/Nlrc4^em2Vnce
• Genetic Background: C57BL/6-Nlrc4^em2Vnce

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased lactate dehydrogenase level ( J:294930 )

• 50% reduction in LDH released by bone marrow derived macrophages (BMDMs) exposed to low doses of cytosolic Legionella pneumophila flagellin

• normal level of LDH released by BMDMs exposed to high doses of cytosolic L. pneumophila flagellin

immune system

decreased inflammatory response ( J:294930 )

• severely reduced inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin or to Salmonella Typhimurium

• normal inflammatory response to systemic injection with L. pneumophila flagellin

mortality/aging

mortality/aging ( J:294930 )

N • viable

reproductive system

reproductive system phenotype ( J:294930 )

N • fertile