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Phenotypes Associated with This Genotype
Genotype
MGI:6509036
Allelic
Composition		 Eps15tm1c(KOMP)Wtsi/Eps15tm1c(KOMP)Wtsi
Eps15l1tm1.1Noff/Eps15l1tm1.1Noff
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eps15l1tm1.1Noff mutation (0 available); any Eps15l1 mutation (80 available)
Eps15tm1c(KOMP)Wtsi mutation (0 available); any Eps15 mutation (66 available)
Tg(Tek-cre)1Ywa mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased mean corpuscular volume ( J:272122 )
• newborn mice show a significant reduction of MCV in peripheral blood
increased red blood cell distribution width ( J:272122 )
• newborn mice show a significant increase in RBC distribution width
anisocytosis ( J:272122 )
• May-Grunwald-Giemsa staining of blood smears from newborn mice indicates presence of anisotropic RBCs
reticulocytosis ( J:272122 )
• May-Grunwald-Giemsa staining revealed a significant increase in reticulocyte number

cardiovascular system
abnormal vascular development ( J:272122 )
• mice exhibit only a mild vascular defect

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory