Phenotypes Associated with This Genotype

Genotype
MGI:6506449

• Allelic Composition: Dnm2^tm1Ueli/Dnm2^tm2.1Ics; Tg(Mpz-cre)26Mes/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

demyelination ( J:288372 )

• mice show severe demyelinating neuropathy

• nerves show a strong reduction of myelinated axons at P24, with an increase in the number of sorted myelin-competent axons that are not enwrapped by myelin

• cells with engulfed myelin inclusions, indicative of ongoing demyelination, are commonly seen in nerves at P24

• however, the number of sorted axons and numbers of structural myelin aberrations are not changed

• no morphological changes are seen in tibial nerves or sciatic nerves at P5, indicating normal radial axonal sorting and correct onset of myelination

abnormal action potential ( J:288372 )

• electrophysiology shows decreased compound muscle action potential amplitude at P24

decreased nerve conduction velocity ( J:288372 )

• electrophysiology shows reduced motor nerve conduction velocity at P24

• compound sensory nerve conduction velocity and compound sensory amplitude are not detectible in P24 mice