Phenotypes for Spo11 Stag3 MGI:6506426 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Spo11^tm1Mjn/Spo11⁺ Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
Genetic Background	B6.Cg-Spo11^tm1Mjn Stag3^{tm1e.1(KOMP)Wtsi}/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11^tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
Stag3^{tm1e.1(KOMP)Wtsi} mutation (1 available); any Stag3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal double-strand DNA break repair ( J:280261 )

• complete absence of double-strand DNA breaks in 77% of zygotene spermatocytes and 50% reduction (compared to either single KO) in remaining 23% of spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• complete absence of double-strand DNA breaks in 77% of zygotene spermatocytes and 50% reduction (compared to either single KO) in remaining 23% of spermatocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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