Phenotypes Associated with This Genotype

Genotype
MGI:6506415

• Allelic Composition: Prdm9^tm1Ymat/Prdm9^tm1Ymat; Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
• Genetic Background: B6.Cg-Prdm9^tm1Ymat Stag3^{tm1e.1(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal male meiosis ( J:280261 )

♂ • reduced number (30% of WT, 27-56% of either single KO) of recombination hotspots in leptotene-like spermatocytes

cellular

abnormal male meiosis ( J:280261 )

♂ • reduced number (30% of WT, 27-56% of either single KO) of recombination hotspots in leptotene-like spermatocytes

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (20-30% of WT or either single KO) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (20-30% of WT or either single KO) in spermatocytes