Phenotypes for Prdm9 Rec8 MGI:6506408 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Prdm9^tm1Ymat/Prdm9^tm1Ymat Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}
Genetic Background	B6.Cg-Prdm9^tm1Ymat Rec8^{tm1b(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9^tm1Ymat mutation (3 available); any Prdm9 mutation (46 available)
Rec8^{tm1b(KOMP)Wtsi} mutation (1 available); any Rec8 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (60-80% of WT or single KO) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (60-80% of WT or single KO) in spermatocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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