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Phenotypes Associated with This Genotype
Genotype
MGI:6506394
Allelic
Composition		 Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Rec8tm1b(KOMP)Wtsi/Rec8tm1b(KOMP)Wtsi
Genetic
Background		 B6N(Cg)-Rad21ltm1b(KOMP)Wtsi Rec8tm1b(KOMP)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21ltm1b(KOMP)Wtsi mutation (1 available); any Rad21l mutation (34 available)
Rec8tm1b(KOMP)Wtsi mutation (1 available); any Rec8 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal double-strand DNA break repair ( J:280261 )
• reduced number of double-strand DNA breaks (20-30% of WT or single KO) in spermatocytes

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:280261 )
• reduced number of double-strand DNA breaks (20-30% of WT or single KO) in spermatocytes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory