Phenotypes for Rad21l Stag3 MGI:6506392 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rad21l^{tm1b(KOMP)Wtsi}/Rad21l^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
Genetic Background	B6N(Cg)-Rad21l^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21l^{tm1b(KOMP)Wtsi} mutation (1 available); any Rad21l mutation (34 available)
Stag3^{tm1e.1(KOMP)Wtsi} mutation (1 available); any Stag3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal synaptonemal complex ( J:280261 )

• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

cellular

abnormal synaptonemal complex ( J:280261 )

• absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (77% of WT) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

• reduced number of double-strand DNA breaks (77% of WT) in spermatocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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