Phenotypes Associated with This Genotype

Genotype
MGI:6506390

• Allelic Composition: Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}; Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Rec8^{tm1b(KOMP)Wtsi} Stag3^{tm1e.1(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal male meiosis ( J:280261 )

♂ • reduced number (25% of WT, 42-61% of either single KO) of recombination hotspots in leptotene-like spermatocytes

abnormal synaptonemal complex ( J:280261 )

♂ • absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

cellular

abnormal male meiosis ( J:280261 )

♂ • reduced number (25% of WT, 42-61% of either single KO) of recombination hotspots in leptotene-like spermatocytes

abnormal synaptonemal complex ( J:280261 )

♂ • absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (40% of either single KO or 60% of WT) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (40% of either single KO or 60% of WT) in spermatocytes