Phenotypes Associated with This Genotype

Genotype
MGI:6506386

• Allelic Composition: Rec8^{tm1b(KOMP)Wtsi}/Rec8^{tm1b(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Rec8^{tm1b(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal male meiosis ( J:280261 )

♂ • reduced number (80% of WT) of recombination hotspots in leptotene-like spermatocytes

cellular

abnormal male meiosis ( J:280261 )

♂ • reduced number (80% of WT) of recombination hotspots in leptotene-like spermatocytes

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (77% of WT) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (77% of WT) in spermatocytes