Phenotypes for Card11 MGI:6491992 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Card11^em1Welu/Card11⁺
Genetic Background	involves: C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11^em1Welu mutation (0 available); any Card11 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased transitional stage T1 B cell number ( J:292926 )

decreased transitional stage T3 B cell number ( J:292926 )

increased transitional stage T2 B cell number ( J:292926 )

decreased marginal zone B cell number ( J:292926 )

impaired humoral immune response ( J:292926 )

• mice show intermediate defects in the marginal zone and B1 B cell development, and the transitional B cell populations from T1 to T3 compared to homozygous mice

hematopoietic system

decreased transitional stage T1 B cell number ( J:292926 )

decreased transitional stage T3 B cell number ( J:292926 )

increased transitional stage T2 B cell number ( J:292926 )

decreased marginal zone B cell number ( J:292926 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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