Phenotypes Associated with This Genotype

Genotype
MGI:6490364

• Allelic Composition: Stag2^tm1.1Alos/Y; Tg(CAG-cre)1Nagy/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:298088 )

♂ • mice die between E9.5 and E12.5

cardiovascular system

abnormal cardiac outflow tract development ( J:298088 )

♂ • shortened length and rightward turning at the junction with the ventricular myocardium in mildly affect mice at E9.5

abnormal heart development ( J:298088 )

♂ • distended atria and ventricles at E9.5

♂ • distended OFT and IFT

♂ • severe cardiac anomalies at E10.5 in all mice with extensive necrosis and apoptosis

common atrium ( J:298088 )

♂

decreased heart right ventricle size ( J:298088 )

♂ • in mildly affect mice at E9.5

cellular

decreased cell proliferation ( J:298088 )

♂ • in E9.5 embryos

embryo

embryonic growth retardation ( J:298088 )

♂ • indicated by reduced somite number at E9.5 measuring a day behind

decreased embryo size ( J:298088 )

♂ • mild and severe at E9.5

growth/size/body

embryonic growth retardation ( J:298088 )

♂ • indicated by reduced somite number at E9.5 measuring a day behind

decreased embryo size ( J:298088 )

♂ • mild and severe at E9.5