Phenotypes Associated with This Genotype

Genotype
MGI:6490362

• Allelic Composition: Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/Ndor1⁺; Stag2^tm1.1Alos/Stag2^tm1.1Alos
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:298088 )

♀ • 4 weeks after initiation of tamoxifen treatment

cellular

abnormal mitosis ( J:298088 )

♀ • tamoxifen-treated mouse embryonic fibroblasts exhibit increased chromosome adhesion and mis-segregation compared with control cells

increased fibroblast apoptosis ( J:298088 )

♀ • increased caspase-3-positive cells in tamoxifen-treated mouse embryonic fibroblasts

cellular necrosis ( J:298088 )

♀ • 8 week old tamoxifen-treated mice exhibit increased intestinal erosion and necrosis compared with wild-type mice

abnormal enterocyte proliferation ( J:298088 )

♀ • reduced in intestinal crypts of tamoxifen-treated mice indicating reduced cellular renewal

decreased fibroblast proliferation ( J:298088 )

♀ • increased doubling time in tamoxifen-treated mouse embryonic fibroblasts

digestive/alimentary system

abnormal enterocyte proliferation ( J:298088 )

♀ • reduced in intestinal crypts of tamoxifen-treated mice indicating reduced cellular renewal

abnormal intestine morphology ( J:298088 )

♀ • 8 week old tamoxifen-treated mice exhibit increased intestinal erosion and necrosis compared with wild-type mice

growth/size/body

decreased body weight ( J:298088 )

♀ • in tamoxifen-treated mice

hematopoietic system

hematopoietic system phenotype ( J:298088 )

♀ • tamoxifen-treated mice exhibit normal adult hematopoiesis

abnormal hematopoietic stem cell physiology ( J:298088 )

♀ • enhanced self-renewal in cells from tamoxifen-treated mice

neoplasm

neoplasm ( J:298088 )

♀ • tamoxifen-treated mice do not exhibit increased spontaneous tumors