Phenotypes Associated with This Genotype

Genotype
MGI:6488501

• Allelic Composition: Adtrp^em1Sagh/Adtrp^em1Sagh; Aig1^em1Sagh/Aig1^em1Sagh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:289837 )

N • no significant changes in the abundance of any of the major lipid classes

N • no change in glucose metabolism

increased fatty acids level ( J:289837 )

• increase in 9-fatty acid esters of hydroxy fatty acids (9-FAHFAs) in brown and white adipose tissue

• increase in adipose tissue is similar to that seen in mice homozygous for Adtrp^em1Sagh alone

• unlike single homozygous mice, 9-FAHFA levels are also increased in kidneys

abnormal lipid metabolism ( J:289837 )

• decrease in 9-palmitic acid hydroxy stearic acid hydrolysis in multiple tissues

• decrease is additive compared to single homozygous mice in the kidney and brown adipose tissue