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Phenotypes Associated with This Genotype
Genotype
MGI:6488233
Allelic
Composition
Btbd9tm1c(EUCOMM)Wtsi/Btbd9tm1c(EUCOMM)Wtsi
Emx1tm1(cre)Yql/Emx1+
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N
Cell Lines EPD0631_3_A09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btbd9tm1c(EUCOMM)Wtsi mutation (0 available); any Btbd9 mutation (40 available)
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit a 219% increase of slips in the beam walking test
• however, mice do not show a deficit in the rotarod test
• in the continuous open field test, mice show an increase in activity level during the light phase but not dark phase indicating a rest-phase specific motor restlessness
• however, mice exhibit a similar level of total distance traveled in a 30 min open field test as controls and similar wheel running activity during both the light and dark phase as in controls
• mice exhibit lower sensitivity to the heat stimuli than controls in the tail-flick test, indicating decreased thermal sensory perception
• sleep analysis indicates an increased probability of waking in the light phase but not dark phase

nervous system
• mice exhibit thinner cortical layers in the posterior primary motor cortex
• mice exhibit thinner cortical layers in both the anterior and posterior part of the primary somatosensory cortex representing the hindlimb

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
restless legs syndrome DOID:0050425 OMIM:PS102300
J:282582


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory