Phenotypes Associated with This Genotype

Genotype
MGI:6480498

• Allelic Composition: Lpxn^{tm1b(EUCOMM)Hmgu}/Lpxn^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Lpxn^{tm1b(EUCOMM)Hmgu}/Wtsi
• Cell Lines: HEPD0688_2_B07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal plasma cell differentiation ( J:305662 )

• decreased differentiation upon stimulation with LPS

• however, mice exhibit normal differentiation after stimulation with anti-CD40 antibody and plasma cell survival

decreased IgM level ( J:305662 )

immune system

immune system phenotype ( J:305662 )

N • mice exhibit normal IgG1 class switch recombination after stimulation with anti-CD40 antibody and IL4 or LPS and IL4, germinal center and plasma cell generation at steady state, and plasma cell generation after T-dependent or T-independent immunization

abnormal plasma cell differentiation ( J:305662 )

• decreased differentiation upon stimulation with LPS

• however, mice exhibit normal differentiation after stimulation with anti-CD40 antibody and plasma cell survival

decreased IgM level ( J:305662 )