Phenotypes Associated with This Genotype

Genotype
MGI:6478929

• Allelic Composition: Bub1b^tm2.1Jvd/Bub1b⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal chromosome number ( J:293084 )

• 18% of mitotic splenocytes show abnormal chromosome numbers

aneuploidy ( J:293084 )

• mouse embryo fibroblasts (MEFs) show an elevation in aneuploidy

• aneuploidy is increased in livers and lungs, but not spleen

abnormal mitosis ( J:293084 )

• MEFs and mitotic splenocytes exhibit premature chromatid separation

• MEFs exhibit small, but significant, increase in chromosome segregation errors; both spindle assembly checkpoint and attachment error correction machinery are impaired

• MEFs exhibit increased chromosome lagging, forming non-perpendicular spindles and elevated rates due to slow centrosome movement

abnormal mitotic spindle assembly checkpoint ( J:293084 )

• spindle assembly checkpoint is impaired in MEFs

abnormal mitotic spindle morphology ( J:293084 )

• MEFs form non-perpendicular spindles