Phenotypes Associated with This Genotype

Genotype
MGI:6478810

• Allelic Composition: Orm2^{tm1(KOMP)Vlcg}/Orm2^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Orm2^{tm1(KOMP)Vlcg}/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

kidney inflammation ( J:292194 )

• mice show exacerbated renal inflammation and macrophage infiltration after unilateral ureteral obstruction compared to wild-type mice

renal fibrosis ( J:292194 )

• mice show exacerbated renal fibrosis after unilateral ureteral obstruction compared to wild-type mice

• treatment with Am80, a synthetic retinoic acid receptor agonist, has no effect on unilateral ureteral obstruction-induced renal fibrosis

• treatment with all-trans retinoic acid has a partial anti-fibrotic effect on unilateral ureteral obstruction-induced renal fibrosis

immune system

kidney inflammation ( J:292194 )

• mice show exacerbated renal inflammation and macrophage infiltration after unilateral ureteral obstruction compared to wild-type mice