Phenotypes Associated with This Genotype

Genotype
MGI:6477398

• Allelic Composition: Trp63^tm3.1Aam/Trp63⁺
• Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

cleft palate ( J:294158 )

• 2.3% of neonates exhibit cleft palate

cellular

decreased keratinocyte proliferation ( J:294158 )

• primary keratinocytes exhibit reduced proliferation

digestive/alimentary system

cleft palate ( J:294158 )

• 2.3% of neonates exhibit cleft palate

growth/size/body

cleft palate ( J:294158 )

• 2.3% of neonates exhibit cleft palate

integument

abnormal keratinocyte physiology ( J:294158 )

• primary keratinocytes exhibit reduced proliferation and a corresponding increases in cellular senescence

• however, no major skin abnormalities are seen at E16.5 or P0

decreased keratinocyte proliferation ( J:294158 )

• primary keratinocytes exhibit reduced proliferation