Phenotypes Associated with This Genotype

Genotype
MGI:6477395

• Allelic Composition: Trp63^tm3.1Aam/Trp63^tm3.1Aam
• Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:294158 )

embryo

abnormal embryo development ( J:294158 )

• defects in epithelial morphogenesis

integument

abnormal skin development ( J:294158 )

• neonates lack a mature skin barrier

limbs/digits/tail

abnormal limb morphology ( J:294158 )

• neonates exhibit severe limb defects including limb truncations

short limbs ( J:294158 )

• limb truncations