Phenotypes Associated with This Genotype

Genotype
MGI:6476970

• Allelic Composition: Wfdc2^em1Fcw/Wfdc2^em1Fcw
• Genetic Background: involves: C57

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung morphology ( J:293623 )

• pale color

decreased pulmonary endothelial cell surface ( J:293623 )

abnormal lung interstitium morphology ( J:293623 )

• significant thickening of alveolar interstitium

abnormal pulmonary alveolar system morphology ( J:293623 )

• reduced number of alveoli

• irregular size and arrangement

decreased type I pneumocyte number ( J:293623 )

• reduced number of mature cells

• increased apoptosis

respiratory distress ( J:293623 )

• heavy, high-frequency (up to 120 breaths per minute) and open-mouth breathing

• intercostal skin depressions

mortality/aging

neonatal lethality, complete penetrance ( J:293623 )

• lethality between 4 and 10 hours after birth

hematopoietic system

hematopoietic system phenotype ( J:293623 )

N • normal spleen morphology

homeostasis/metabolism

decreased blood oxygen saturation level ( J:293623 )

cyanosis ( J:293623 )

• progressive, from 2 hours after birth

cardiovascular system

cardiovascular system phenotype ( J:293623 )

N • normal heart morphology

decreased pulmonary endothelial cell surface ( J:293623 )

growth/size/body

growth/size/body region phenotype ( J:293623 )

N • normal body weight