Phenotypes Associated with This Genotype

Genotype
MGI:6476965

• Allelic Composition: Obsl1^tm1.1Slan/Obsl1^tm1.1Slan; Tg(Myog-cre)1Eno/0
• Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:283623 )

N • mice do not exhibit premature death or gross morphological abnormalities

muscle

muscle phenotype ( J:283623 )

N • mice exhibit normal sarcomerogenesis in tibialis anterior (TA) muscles; Z-disc and M-band structures are not significantly altered

N • no significant changes are observed in the number of centralized nuclei in TA muscle at 4 months of age

increased extensor digitorum longus weight ( J:283623 )

• at 4 months of age, muscle weight to tibia-length ratio is slightly increased for extensor digitorum longus (EDL) muscles

• however, muscle weight to tibia-length ratios for TA, soleus, and gastrocnemius are normal

increased skeletal muscle fiber diameter ( J:283623 )

• analysis of cross-sectional areas in TA muscles revealed an increase in fiber size

limbs/digits/tail

increased extensor digitorum longus weight ( J:283623 )

• at 4 months of age, muscle weight to tibia-length ratio is slightly increased for extensor digitorum longus (EDL) muscles

• however, muscle weight to tibia-length ratios for TA, soleus, and gastrocnemius are normal