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Phenotypes Associated with This Genotype
Genotype
MGI:6476763
Allelic
Composition
Cd2apem1Irgu/Cd2apem1Irgu
Genetic
Background
C57BL/6-Cd2apem1Irgu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd2apem1Irgu mutation (0 available); any Cd2ap mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice fail to thrive and clear growth retardation is seen after 5 to 6 weeks

homeostasis/metabolism
• serum creatinine levels are elevated at 4 to 6 weeks of age
• blood urea nitrogen levels are elevated at 4 to 6 weeks of age
• serum albumin levels are decreased at 4 to 6 weeks of age
• mice exhibit albuminuria as early as 2 to 3 weeks of age

immune system
• kidneys show interstitial leukocyte infiltration

mortality/aging
• mice die between 6 and 8 weeks of age, most likely from kidney failure

renal/urinary system
• mice exhibit albuminuria as early as 2 to 3 weeks of age
• kidneys show interstitial leukocyte infiltration
• minor glomerulosclerosis is seen as early as 2 weeks of age which becomes more pronounced at 4 to 6 weeks of age
• kidneys show some tubular atrophy at 2 weeks of age which becomes more pronounced at 4 to 6 weeks of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/13/2022
MGI 6.21
The Jackson Laboratory