Phenotypes Associated with This Genotype

Genotype
MGI:6476688

• Allelic Composition: Des^tm1Cba/Des^tm1Cba; Synm^tm1.1Ics/Synm^tm1.1Ics
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:268425 )

N • in toto X-gal staining revealed that double mutant embryos show no differences in the pattern of desmin-LacZ expression in skeletal and cardiac muscle relative to control embryos, indicating normal muscle and cardiac formation (E11.5) and patterning (E13.5)

abnormal myoblast differentiation ( J:268425 )

• in neonatal hindlimb muscle cell cultures, the percentage of LacZ-positive myoblasts per myogenic colony is on average 16% higher than that in control cultures, suggesting that primary muscle cells commit to myogenic differentiation earlier than wild-type cells

cellular

abnormal myoblast differentiation ( J:268425 )

• in neonatal hindlimb muscle cell cultures, the percentage of LacZ-positive myoblasts per myogenic colony is on average 16% higher than that in control cultures, suggesting that primary muscle cells commit to myogenic differentiation earlier than wild-type cells