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Phenotypes Associated with This Genotype
Genotype
MGI:6467523
Allelic
Composition
Lrrc8aem1Uia/Lrrc8aem1Uia
Tg(Adipoq-cre)1Evdr/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc8aem1Uia mutation (0 available); any Lrrc8a mutation (53 available)
Tg(Adipoq-cre)1Evdr mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
N
• mice exhibit normal adipocyte development
• when fed a high-fat diet
• when fed a high-fat diet, adipocyte size is shifted toward a lean phenotype compared with wild-type cells
• when fed a high-fat diet
• when fed a high-fat diet

homeostasis/metabolism
• when fed a high-fat diet despite normal daily food consumption
• when fed a high-fat diet
• however, mice fed standard chow exhibit normal energy expenditure
• whether mice are fed a high-fat diet or standard chow
• whether mice are fed a high-fat diet or standard chow

behavior/neurological
• when fed a high-fat diet

growth/size/body
• when fed a high-fat diet despite normal daily food consumption


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory