Phenotypes Associated with This Genotype

Genotype
MGI:6467014

• Allelic Composition: Il36g^tm1Lex/Il36g^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:264077 )

• mice exhibit greater mortality following influenza A PR8 infection than wild-type mice

• mice infected with the less pathogenic H3N2 influenza A/HKx31 virus show greater mortality than wild-type mice

• mice receiving a transfer of wild-type alveolar macrophages show an increase in survival following influenza A infection

immune system

increased macrophage apoptosis ( J:264077 )

• alveolar macrophage frequency and numbers rapidly decline following influenza A x31 infection and this loss is associated with a rapid increase in macrophage apoptosis

increased CD11b-high dendritic cell number ( J:264077 )

• influenza A x31-infected mice show increased numbers of CD11b^hi dendritic cells at 3 dpi but not 6 dpi

abnormal macrophage morphology ( J:264077 )

• alveolar macrophages from naive mice are skewed toward an M2-like macrophage polarization

decreased alveolar macrophage number ( J:264077 )

• influenza A x31-infected mice show decreased number of alveolar macrophages at 3 and 6 dpi

abnormal interleukin level ( J:264077 )

• BAL fluid of mice infected with a high dose of influenza A x31 shows increased IL-6 levels, but not IFN-gamma, TNF, or IL-1alpha

abnormal tumor necrosis factor level ( J:264077 )

• BAL fluid of mice infected with a high dose of influenza A x31 shows increased IFN-beta levels

increased susceptibility to Orthomyxoviridae infection ( J:264077 )

• influenza A PR8 infected mice exhibit increased viral load 6 days post infection (dpi) and greater mortality than controls

• influenza A x31 infected mice exhibit increased viral load, increased weight loss, greater mortality, and more diffuse immune infiltrate around the bronchioles than wild-type mice

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:264077 )

• mice exhibit greater mortality following influenza A PR8 infection than wild-type mice

• mice infected with the less pathogenic H3N2 influenza A/HKx31 virus show greater mortality than wild-type mice

• mice receiving a transfer of wild-type alveolar macrophages show an increase in survival following influenza A infection

growth/size/body

increased susceptibility to weight loss ( J:264077 )

• mice infected with influenza A x31 show increased weight loss beginning on day 3 post infection

hematopoietic system

increased macrophage apoptosis ( J:264077 )

• alveolar macrophage frequency and numbers rapidly decline following influenza A x31 infection and this loss is associated with a rapid increase in macrophage apoptosis

increased CD11b-high dendritic cell number ( J:264077 )

• influenza A x31-infected mice show increased numbers of CD11b^hi dendritic cells at 3 dpi but not 6 dpi

abnormal macrophage morphology ( J:264077 )

• alveolar macrophages from naive mice are skewed toward an M2-like macrophage polarization

decreased alveolar macrophage number ( J:264077 )

• influenza A x31-infected mice show decreased number of alveolar macrophages at 3 and 6 dpi

homeostasis/metabolism

abnormal interleukin level ( J:264077 )

• BAL fluid of mice infected with a high dose of influenza A x31 shows increased IL-6 levels, but not IFN-gamma, TNF, or IL-1alpha

abnormal tumor necrosis factor level ( J:264077 )

• BAL fluid of mice infected with a high dose of influenza A x31 shows increased IFN-beta levels

respiratory system

decreased alveolar macrophage number ( J:264077 )

• influenza A x31-infected mice show decreased number of alveolar macrophages at 3 and 6 dpi

cellular

increased macrophage apoptosis ( J:264077 )

• alveolar macrophage frequency and numbers rapidly decline following influenza A x31 infection and this loss is associated with a rapid increase in macrophage apoptosis