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Phenotypes Associated with This Genotype
Genotype
MGI:6467004
Allelic
Composition		 H2-Q10tm1.1(KOMP)Mbp/H2-Q10tm1.1(KOMP)Mbp
Genetic
Background		 involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Q10tm1.1(KOMP)Mbp mutation (1 available); any H2-Q10 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased NK cell number ( J:294888 )
• reduced conventional NK (cNK) cell number and percentage in liver
• reduced CD27-/CD11b+ conventional NK (cNK) cell number and percentage in liver
• reduced CD27+/CD11b+ conventional NK (cNK) cell number in liver
• normal conventional NK (cNK) cell number and percentage in spleen
• normal KLRG1+, CD96+ and TIGIT+ conventional NK (cNK) cell number in liver
decreased immature NK cell number ( J:294888 )
• reduced CD94+/Ly49C- conventional NK (cNK) cell number and frequency in liver
decreased mature NK cell number ( J:294888 )
• reduced CD94-/Ly49C+ conventional NK (cNK) cell number and frequency in liver
increased NK cell number ( J:294888 )
• increased CD27+/CD11b- conventional NK (cNK) cell percentage in liver
• normal KLRG1+, CD96+ and TIGIT+ conventional NK (cNK) cell number in liver
decreased gamma-delta T cell number ( J:294888 )
• reduced CD8a+/CD8a+ cell number and percentage in liver
• normal CD8a+/CD8a+ cell number and percentage in spleen

immune system
decreased NK cell number ( J:294888 )
• reduced conventional NK (cNK) cell number and percentage in liver
• reduced CD27-/CD11b+ conventional NK (cNK) cell number and percentage in liver
• reduced CD27+/CD11b+ conventional NK (cNK) cell number in liver
• normal conventional NK (cNK) cell number and percentage in spleen
• normal KLRG1+, CD96+ and TIGIT+ conventional NK (cNK) cell number in liver
decreased immature NK cell number ( J:294888 )
• reduced CD94+/Ly49C- conventional NK (cNK) cell number and frequency in liver
decreased mature NK cell number ( J:294888 )
• reduced CD94-/Ly49C+ conventional NK (cNK) cell number and frequency in liver
increased NK cell number ( J:294888 )
• increased CD27+/CD11b- conventional NK (cNK) cell percentage in liver
• normal KLRG1+, CD96+ and TIGIT+ conventional NK (cNK) cell number in liver
decreased gamma-delta T cell number ( J:294888 )
• reduced CD8a+/CD8a+ cell number and percentage in liver
• normal CD8a+/CD8a+ cell number and percentage in spleen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory