Phenotypes Associated with This Genotype

Genotype
MGI:6466738

• Allelic Composition: Bpnt2^tm1.2Aros/Bpnt2^tm1.2Aros
• Genetic Background: B6(SJL)-Bpnt2^tm1.2Aros

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:273179 )

• mice die at birth

growth/size/body

cleft palate ( J:273179 )

decreased birth body size ( J:273179 )

• mice are smaller at birth

skeleton

abnormal skeleton morphology ( J:273179 )

• severe hypoplasia of the skeleton

short femur ( J:273179 )

short fibula ( J:273179 )

short tibia ( J:273179 )

abnormal thoracic cage morphology ( J:273179 )

• rib cages display skeletal defects characterized by reduced sternal length and diminished rib spacing

short sternum ( J:273179 )

axial skeleton hypoplasia ( J:273179 )

• length of the axial skeleton is reduced

craniofacial

cleft palate ( J:273179 )

digestive/alimentary system

cleft palate ( J:273179 )

limbs/digits/tail

short femur ( J:273179 )

short fibula ( J:273179 )

short tibia ( J:273179 )

short limbs ( J:273179 )

• length of the limbs is reduced

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chondrodysplasia with joint dislocations gPAPP type		DOID:0112224	OMIM:614078	J:273179