Phenotypes Associated with This Genotype

Genotype
MGI:6460451

• Allelic Composition: Tmem95^em1Beal/Tmem95^em1Beal
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

male infertility ( J:289090 )

♂

impaired fertilization ( J:289090 )

♂ • sperm are unable to fertilize cumulus-oocyte complexes in vitro

♂ • however, sperm are able to travel across the zona pellucida and display normal motility

failure of sperm-egg fusion ( J:289090 )

♂ • sperm undergo acrosome reaction but fail to fuse with the egg membrane

♂ • however, sperm are able to bind to the oolemma

♂ • bypassing fusion by intracytoplasmic injection results in successful fertilization