Phenotypes Associated with This Genotype

Genotype
MGI:6460135

• Allelic Composition: Ikzf4^tm1.1Etms/Ikzf4^tm1.1Etms
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:295208 )

N • normal immune organ cellularity

N • normal percentages of different immune cell types in spleen, with slight reduction in CD19+ cells

N • normal serum Ig levels

N • normal suppression of WT T cells in vivo and in vitro

decreased T cell proliferation ( J:295208 )

• less vigorous proliferation of conventional T cells when stimulated in vitro

increased susceptibility to experimental autoimmune encephalomyelitis ( J:295208 )

• more severe phenotype, including death, and inability to recover from paralysis

chronic inflammation ( J:294549 )

• increased lymphocyte infiltration in small intestine, lungs, liver, salivary glands and kidneys at age 12 months

hematopoietic system

hematopoietic system phenotype ( J:295208 )

N • complete blood count shows normal numbers of innate cells, with slight increase in polymorphonuclear leukocytes and monocytes

N • normal serum Ig levels

N • normal regulatory T cell numbers and percentages in spleen, lymph nodes and thymus

N • normal splenocyte homeostatic proliferation

decreased T cell proliferation ( J:295208 )

• less vigorous proliferation of conventional T cells when stimulated in vitro

cellular

decreased T cell proliferation ( J:295208 )

• less vigorous proliferation of conventional T cells when stimulated in vitro