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Phenotypes Associated with This Genotype
Genotype
MGI:6460092
Allelic
Composition
Rhebtm1Pfw/Rhebtm1Pfw
Tg(Amh-cre)8815Reb/0
Genetic
Background
involves: 129S1/SvImJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhebtm1Pfw mutation (0 available); any Rheb mutation (25 available)
Tg(Amh-cre)8815Reb mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• adult males are fertile, have many normal sperm present in the epididymis, and show normal distribution of vimentin filaments in Sertoli cells (SCs) at 2 months of age, suggesting normal SC cytoskeletal organization
• 70% reduction in sperm count at 2 months of age
• adult mice display only mild morphological alterations in the seminiferous tubules
• 60% reduction in testis weight at 2 months of age
• 54% reduction in epididymis weight at 2 months of age

cellular
• 70% reduction in sperm count at 2 months of age

endocrine/exocrine glands
• adult mice display only mild morphological alterations in the seminiferous tubules
• 60% reduction in testis weight at 2 months of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory