Phenotypes Associated with This Genotype

Genotype
MGI:6459875

• Allelic Composition: Insyn1^em1Ssod/Insyn1^em1Ssod
• Genetic Background: C57BL/6J-Insyn1^em1Ssod

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dentate gyrus morphology ( J:284536 )

• following contextual fear memory retrieval, mice show 26% increase of c-Fos-positive cells in the dentate gyrus

abnormal hippocampus neuron morphology ( J:284536 )

• at DIV13, primary hippocampal neurons show altered alpha-dystroglycan (but not gephyrin) spatial distribution and GABA_A receptor composition at inhibitory synapses

abnormal inhibitory synapse morphology ( J:284536 )

• at DIV13, primary hippocampal neurons show altered alpha-dystroglycan (but not gephyrin) spatial distribution and GABA_A receptor composition at inhibitory synapses

abnormal hippocampus physiology ( J:284536 )

• mice exhibit elevated neuronal activity in the dentate gyrus

abnormal nervous system electrophysiology ( J:284536 )

• cortical neurons display elevated neuronal excitation with significant perturbations in neuronal bursting in vitro

abnormal neuron physiology ( J:284536 )

• following contextual fear memory retrieval, mice show 26% increase of c-Fos-positive cells in the dentate gyrus, indicating increased neuronal activity

behavior/neurological

behavior/neurological phenotype ( J:284536 )

N • mice show normal sensitivity to seizure induction by flurothyl (a GABA receptor antagonist) as well as normal memory in a novel object recognition test and normal anxiety levels in the open field and light-dark box tests

impaired contextual conditioning behavior ( J:284536 )

• in the contextual fear conditioning paradigm, mice show a marked decrease in conditioned freezing to the context 24 after the foot shock, indicating impaired contextual fear memory

decreased locomotor activity ( J:284536 )

• mice exhibit a slight but significant decrease in total distance traveled in the open field test as well as decreased total activity in the light-dark box paradigm