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Phenotypes Associated with This Genotype
Genotype
MGI:6459272
Allelic
Composition		 Vps4atm1.2Thkn/Vps4a+
Vps4btm1Thkn/Vps4b+
Genetic
Background		 B6.129S2(Cg)-Vps4btm1Thkn Vps4atm1.2Thkn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vps4atm1.2Thkn mutation (0 available); any Vps4a mutation (17 available)
Vps4btm1Thkn mutation (0 available); any Vps4b mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell morphology ( J:236761 )
• mouse embryonic fibroblasts exhibit increased endo/lysosomal organelles with large multi-membrane structures compared with control cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory