Phenotypes Associated with This Genotype

Genotype
MGI:6458490

• Allelic Composition: Tg(Thy1/THY1)hT13Gsv/0
• Genetic Background: involves: C57BL/10 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:133943 )

neoplasm

increased papilloma incidence ( J:133943 )

• brain of one mouse shows a papillomatous neoplasm of the choroid plexus that fills the third and fourth ventricles; cells show cytological atypia

increased kidney tumor incidence ( J:133943 )

• mice develop cystic neoplasms in the kidney derived from the proximal tubules through an intermediate in situ tumor

renal/urinary system

increased kidney tumor incidence ( J:133943 )

• mice develop cystic neoplasms in the kidney derived from the proximal tubules through an intermediate in situ tumor

abnormal renal tubule epithelium morphology ( J:133943 )

• in some tubules, the epithelial cells show nuclear variability, and increase in nuclear size, and a high mitotic rate, leading to closure of the tubules