Phenotypes Associated with This Genotype

Genotype
MGI:6457282

• Allelic Composition: Opn3^{tm2c(EUCOMM)Wtsi}/Opn3^{tm2c(EUCOMM)Wtsi}; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: C57BL/6N * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal beige fat cell morphology ( J:287419 )

• low beige content in inguinal white adipose tissue

abnormal white fat cell size ( J:287419 )

• larger size distribution

abnormal adipose tissue physiology ( J:287419 )

• fed and fasted, cold-exposed mice impaired fat mobilization compared with control mice

homeostasis/metabolism

impaired adaptive thermogenesis ( J:287419 )

• reduced core body temperature following cold-exposure under full spectrum lighting

• however, mice raised without 480 nm light exhibit normal cold exposure response and tail temperatures are normal

abnormal circulating glycerol level ( J:287419 )

• unlike wild-type mice, fasted mice exhibit reduced elevation of serum glycerol compared with fed mice

decreased core body temperature ( J:287419 )

• following cold-exposure