Phenotypes Associated with This Genotype

Genotype
MGI:6455140

• Allelic Composition: Exosc10^em1Dean/Exosc10^em1Dean
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal oocyte morphology ( J:293856 )

♀ • oocytes exhibit defective germinal vesicle breakdown with impaired endomembrane components, including endosomes, lysosomes, endoplasmic reticulum and Golgi compared with wild-type cells

♀ • diameter modestly reduced

decreased oocyte number ( J:293856 )

♀ • fewer oocytes are recovered following gonadotropin stimulation

reduced female fertility ( J:293856 )

♀ • female mice produce smaller litters

decreased litter size ( J:293856 )

♀ • female mice produce smaller litters

embryo

abnormal blastocyst formation ( J:293856 )

♀ • some embryos from female mice fail to progress normally during pre-implantation and do not form blastocysts

cellular

abnormal oocyte morphology ( J:293856 )

♀ • oocytes exhibit defective germinal vesicle breakdown with impaired endomembrane components, including endosomes, lysosomes, endoplasmic reticulum and Golgi compared with wild-type cells

♀ • diameter modestly reduced

decreased oocyte number ( J:293856 )

♀ • fewer oocytes are recovered following gonadotropin stimulation