Phenotypes Associated with This Genotype

Genotype
MGI:6452090

• Allelic Composition: Pld3^em1Nemz/Pld3^em1Nemz
• Genetic Background: C57BL/6J-Pld3^em1Nemz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:281205 )

N • no elevation of expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages

N • normal splenic NK T cell number

N • normal macrophage response to TLR4 agonist lipopolysaccharide

immune system

immune system phenotype ( J:281205 )

N • normal spleen

increased interleukin-6 secretion ( J:281205 )

• increased thioglycolate-elicited IL6 expression in macrophages in response to A-type CpG ODN 2216PS