Phenotypes Associated with This Genotype

Genotype
MGI:6451057

• Allelic Composition: Apob^tm3Sgy/Apob^tm3Sgy
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

The yolk sac visceral endoderm from Apob^tm3Sgy/Apob^tm3Sgy embryos contains foamy vacuoles

embryo

abnormal embryo development ( J:84977 )

• cholesterol concentrations in intraembryonic tissues at E9.5-10.5 were reduced

abnormal visceral yolk sac endoderm morphology ( J:84977 )

• yolk sac visceral endodermal cells at E9.5 contain at their basal surface numerous small vacuoles, which often appear foamy

• these cells show an accumulation of cytosolic lipid droplets at their basal surface

• these cells contain no lipoproteins in their secretory vesicles

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:23315 )

• incomplete penetrance, most dead by E10.5

nervous system

exencephaly ( J:23315 )

• in mice that survived past E10.5