Phenotypes Associated with This Genotype

Genotype
MGI:6449671

• Allelic Composition: Cul3^tm1Jdsr/Cul3⁺; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129S4/SvJaeSor * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:292173 )

N • normal latency to fall in rotarod test

N • normal distance traveled in open field test

N • normal number of arm entries and spontaneous alterations in Y-maze test

N • normal time and number of grooming episodes

increased anxiety-related response ( J:292173 )

• fewer entries into and time spent in open arms in elevated plus maze test

• normal total distance travelled and time spent in closed arms in elevated plus maze test

increased thigmotaxis ( J:292173 )

• less time spent in center in open field test

• normal distance traveled in open field test

abnormal response to social novelty ( J:292173 )

• reduced social preference index when introduced to novel mouse and novel inanimate object in three-chamber test

• reduced social preference index when introduced to novel mouse and known mouse in three-chamber test

nervous system

nervous system phenotype ( J:292173 )

N • normal cerebral cortex, corpus callosum and hippocampus morphology and brain weight

N • normal latency to localize buried food pellets in olfactory sensing test

N • normal neuron morphology in CA1 and CA3 hippocampal regions and in cerebral neocortex layers at age P60

N • normal length and complexity of apical and basal dendrites of hippocampal CA1 neurons at age P60

N • normal resting membrane potential (RMP) in hippocampal CA1 pyramidal neurons at age P60

N • normal number of inhibitory synapses in hippocampal CA1 pyramidal neurons at age P15

increased dendritic spine density ( J:292173 )

• increased number of spines on apical dendrites of hippocampal CA1 neurons at age P15 and P60

abnormal action potential ( J:292173 )

• increased AP frequency in response to injected currents in hippocampal CA1 pyramidal neurons at age P60

abnormal CNS synaptic transmission ( J:292173 )

• higher rate of successful responses and synaptic efficacy to minimal stimulation in hippocampal CA1 pyramidal neurons at age P60

• increased EPSC/IPSC ratio in hippocampal CA1 pyramidal neurons at age P60

• normal synaptic potency to minimal stimulation in hippocampal CA1 pyramidal neurons at age P60

increased miniature excitatory postsynaptic current frequency ( J:292173 )

• increased mEPSC frequency in hippocampal CA1 pyramidal neurons at age P15 and P60

• normal mEPSC amplitude in hippocampal CA1 pyramidal neurons at age P15 and P60

increased miniature inhibitory postsynaptic current frequency ( J:292173 )

• increased mIPSC frequency in hippocampal CA1 pyramidal neurons at age P60

• normal mIPSC amplitude in hippocampal CA1 pyramidal neurons at age P60

decreased paired-pulse facilitation ( J:292173 )

• reduced paired-pulse ratio in hippocampal CA1 pyramidal neurons at age P60

mortality/aging

mortality/aging ( J:292173 )

N • viable and normal lifespan

growth/size/body

growth/size/body region phenotype ( J:292173 )

N • normal body size

reproductive system

reproductive system phenotype ( J:292173 )

N • fertile