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Phenotypes Associated with This Genotype
Genotype
MGI:6449004
Allelic
Composition
Ly6etm1c(EUCOMM)Hmgu/Ly6etm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Ly6etm1c(EUCOMM)Hmgu Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (21 available)
Ly6etm1c(EUCOMM)Hmgu mutation (1 available); any Ly6e mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice infected with a high dose of mouse hepatitis virus-A59 (MHV) rapidly succumb to infection by day 6 compared to 100% survival in controls

immune system
• MHV-infected males show reduced recruitment of neutrophils to the liver and spleen
• MHV-infected males show reduced recruitment of natural killer cells to the liver and spleen
• by 5 days post MHV-infection and at both low and high doses of MHV, females show reduced presence of mononuclear immune cells in the liver
• MHV-infected males and females show reduced hepatic and spleen B cell numbers
• MHV-infected males and females how reduced recruitment of natural killer cells to the liver and spleen
• MHV-infected females show reduced hepatic CD4+ T cells
• MHV-infected males show reduced recruitment of macrophages to the liver
• at 3 days post MHV-infection, inflammation is moderately reduced in females compared to controls, but not in males
• mice are highly susceptible to mouse hepatitis virus-A59 (MHV) with mice infected with a high dose of MHV rapidly succumbing to infection by day 6
• males show greater susceptibility than females
• females and males infected with MHV show elevated spleen viral burden at both high and lower doses of MHV, however hepatic viral burden is similar in males and females
• viral burden and liver damage are elevated in females at a lower dose of MHV but not in males which exhibit saturated hepatic infection
• bone marrow-derived macrophages are more susceptible to MHV infection
• in splenocyte cultures, MHV infects macrophages, neutrophils, dendritic cells and B cells but not CD4+ or CD8+ T cells
• B cells from both male and female mice are highly susceptible to MHV infection
• mice infected with a high dose of mouse hepatitis virus-A59 (MHV) rapidly succumb to infection by day 6 compared to 100% survival in controls

hematopoietic system
• MHV-infected males show reduced recruitment of neutrophils to the liver and spleen
• MHV-infected males show reduced recruitment of natural killer cells to the liver and spleen
• by 5 days post MHV-infection and at both low and high doses of MHV, females show reduced presence of mononuclear immune cells in the liver
• MHV-infected males and females show reduced hepatic and spleen B cell numbers
• MHV-infected males and females how reduced recruitment of natural killer cells to the liver and spleen
• MHV-infected females show reduced hepatic CD4+ T cells
• MHV-infected males show reduced recruitment of macrophages to the liver

homeostasis/metabolism
• females, but not males, infected with MHV exhibit increased serum alanine aminotransferase levels

liver/biliary system
• females, but not males, infected with MHV exhibit higher levels of liver damage than controls
• by 5 days post MHV-infection and at both low and high doses of MHV, females show higher levels of liver necrosis than males
• mice infected with an intermediate viral dose of MHV exhibit liver pallor

cellular
• by 5 days post MHV-infection and at both low and high doses of MHV, females show higher levels of liver necrosis than males


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory