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Phenotypes Associated with This Genotype
Genotype
MGI:6446738
Allelic
Composition
Hgftm1.1Tbf/Hgftm1.1Tbf
Genetic
Background
B6.Cg-Hgftm1.1Tbf/Tbf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hgftm1.1Tbf mutation (0 available); any Hgf mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• marker analysis indicates a reduction in the number of neural crest-derived melanocytes that infiltrate the developing stria vascularis
• reduction in thickness and total strial area are seen at the base, mid-turn and apex of the cochlea
• mice show a reduction in endocochlear potential at P60
• moderate-to-severe hearing loss at 4 weeks of age which is unchanged at 8 and 25 weeks
• however, distortion-product otoacoustic emissions (DPOAEs) are normal, indicating normal outer hair cell function

pigmentation
• marker analysis indicates a reduction in the number of neural crest-derived melanocytes that infiltrate the developing stria vascularis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive nonsyndromic deafness 39 DOID:0110497 OMIM:608265
J:289982


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory