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Phenotypes Associated with This Genotype
Genotype
MGI:6446222
Allelic
Composition		 Btnl1tm1(KOMP)Mbp/Btnl1tm1(KOMP)Mbp
Gt(ROSA)26Sortm1(rtTA*M2)Jae/0
Tg(tetO-Btnl1)#Ahay/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btnl1tm1(KOMP)Mbp mutation (2 available); any Btnl1 mutation (30 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (1095 available)
Tg(tetO-Btnl1)#Ahay mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut with or without doxycycline administration
• almost total loss of TCRVgamma7GL2+ IELs in the gut with or without doxycycline administration
• normal CD122hi TCRVgamma7+ IELs (most also Ki67+) in the gut after doxycycline administration

immune system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut with or without doxycycline administration
• almost total loss of TCRVgamma7GL2+ IELs in the gut with or without doxycycline administration
• normal CD122hi TCRVgamma7+ IELs (most also Ki67+) in the gut after doxycycline administration

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory