Phenotypes Associated with This Genotype

Genotype
MGI:6445552

• Allelic Composition: Cyrib^m1Dmal/Cyrib^m1Dmal
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal large intestine goblet cell morphology ( J:282597 )

• increased cell counts in caecum after oral infection with Salmonella Typhimurium

endocrine/exocrine glands

abnormal large intestine goblet cell morphology ( J:282597 )

• increased cell counts in caecum after oral infection with Salmonella Typhimurium

hematopoietic system

increased neutrophil cell number ( J:282597 )

• increased polymorphonuclear neutrophil infiltration of gut submucosa after oral infection with Salmonella Typhimurium

abnormal spleen morphology ( J:282597 )

• multiple diffuse abscesses after intravenous infection with Salmonella Typhimurium

abnormal spleen white pulp morphology ( J:282597 )

• marked lymphocytolysis after intravenous infection with Salmonella Typhimurium

immune system

increased neutrophil cell number ( J:282597 )

• increased polymorphonuclear neutrophil infiltration of gut submucosa after oral infection with Salmonella Typhimurium

abnormal spleen morphology ( J:282597 )

• multiple diffuse abscesses after intravenous infection with Salmonella Typhimurium

abnormal spleen white pulp morphology ( J:282597 )

• marked lymphocytolysis after intravenous infection with Salmonella Typhimurium

increased circulating interleukin-10 level ( J:282597 )

• after intravenous infection with Salmonella Typhimurium

increased circulating interleukin-6 level ( J:282597 )

• after intravenous infection with Salmonella Typhimurium

increased circulating tumor necrosis factor level ( J:282597 )

• after intravenous infection with Salmonella Typhimurium

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282597 )

• progressive increase in bacterial load, overall and in spleen and liver after intravenous or oral infection with Salmonella Typhimurium

• elevated levels of circulating bacteria (septicaemia) after intravenous or oral infection with Salmonella Typhimurium

• decreased survival rates after intravenous or oral infection with Salmonella Typhimurium

• higher bacterial load in lungs after infection with M. tuberculosis

• increased parenchymal infiltration by granulomatous reaction and lympho-histiocytic inflammatory cells in lungs after infection with M. tuberculosis

homeostasis/metabolism

intestinal edema ( J:282597 )

• caecal oedema after oral infection with Salmonella Typhimurium

increased circulating interleukin-10 level ( J:282597 )

• after intravenous infection with Salmonella Typhimurium

increased circulating interleukin-6 level ( J:282597 )

• after intravenous infection with Salmonella Typhimurium

increased circulating tumor necrosis factor level ( J:282597 )

• after intravenous infection with Salmonella Typhimurium

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282597 )

• progressive increase in bacterial load, overall and in spleen and liver after intravenous or oral infection with Salmonella Typhimurium

• elevated levels of circulating bacteria (septicaemia) after intravenous or oral infection with Salmonella Typhimurium

• decreased survival rates after intravenous or oral infection with Salmonella Typhimurium

• higher bacterial load in lungs after infection with M. tuberculosis

• increased parenchymal infiltration by granulomatous reaction and lympho-histiocytic inflammatory cells in lungs after infection with M. tuberculosis

liver/biliary system

liver abscess ( J:282597 )

• after intravenous infection with Salmonella Typhimurium

digestive/alimentary system

abnormal large intestine goblet cell morphology ( J:282597 )

• increased cell counts in caecum after oral infection with Salmonella Typhimurium

abnormal cecum morphology ( J:282597 )

• compromised epithelial integrity after oral infection with Salmonella Typhimurium

intestinal edema ( J:282597 )

• caecal oedema after oral infection with Salmonella Typhimurium

respiratory system

pulmonary parenchymal consolidation ( J:282597 )

• large parenchymal consolidation in lungs after infection with M. tuberculosis