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Phenotypes Associated with This Genotype
Genotype
MGI:6444681
Allelic
Composition
Ikbkbem1Macc/Ikbkb+
Genetic
Background
involves: C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbem1Macc mutation (0 available); any Ikbkb mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increase in the number of effector T cells
• small increase in circulating T reg cells and within the thymus
• T cells are reduced as a proportion of splenocytes
• reduction in absolute number of T cells within spleens
• reduction in absolute numbers of CD4+ T cells
• reduction in absolute numbers of CD8+ T cells
• increase in T cell activation

immune system
• increase in the number of effector T cells
• small increase in circulating T reg cells and within the thymus
• T cells are reduced as a proportion of splenocytes
• reduction in absolute number of T cells within spleens
• reduction in absolute numbers of CD4+ T cells
• reduction in absolute numbers of CD8+ T cells
• increase in T cell activation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
immunodeficiency 15A DOID:0111960 OMIM:618204
J:290616


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/14/2022
MGI 6.19
The Jackson Laboratory