Phenotypes Associated with This Genotype

Genotype
MGI:6441978

• Allelic Composition: Tbx6^em3Fzh/Tbx6^em3Fzh
• Genetic Background: C57BL/6J-Tbx6^em3Fzh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal vertebrae morphology ( J:288810 )

• mice exhibit an increased risk of developing congenital vertebral malformations, with 60% of mice showing congenital vertebral malformations at 35-45 days of age

• vertebral defects include fusions and clefts of the vertebrae

• all the affected vertebrae are clustered on the cervical segments and no obvious malformations are seen in the other portions of the spine

• 55% incidence of congenital vertebral malformations at the C1 and C2 positions and 10% at the C3 and C4 positions

vertebral fusion ( J:288810 )

• vertebral defects include fusions